Humanised antibodies having modified allotypic determinants

Details Humanised antibodies having modified allotypic determinants Humanised antibodies having modified allotypic determinants

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2105980

2105980 9216562 PCTABS00016 The invention relates to molecules which have an amino acid sequence derivable from part or all of the constant region of an immunoglobulin heavy chain. The constant regions are of a particular isotype and have one or more allotypic determinants. The amino acid sequence is substantially homologous to the amino acid sequence of the constant region. However, it has been altered so that it is without at least one of said allotypic determinants by making its sequence the site for an allotypic determinant identical to the amino acid sequence from the corresponding position in another equivalent immunoglobulin constant region of a different isotype. The invention provides synthetic immunoglobulins with reduced allotypic differences as compared to a given wild-type immunoglobulin.

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