Humanization of an anti-carcinoembryonic antigen...

Details Humanization of an anti-carcinoembryonic antigen... Humanization of an anti-carcinoembryonic antigen...

Category

C - Chemistry, Metallurgy

Subcategory

12

Subsubcategory

N

IPC codes

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)

Type

Patent

Patent number

CA 2250080

Description

A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as a clearing agent for anti- CEA antibodies or antibody fragments. The humanized anti-idiotype also can be used as an immunogenic vaccine.

Forme humanisée d'un anticorps anti-idiotype contre l'antigène carcino-embryonnaire (CEA), par exemple, hWI2, présentant une immuno-réactivité préservée. On amplifie les avantages cliniques d'anticorps anti-CEA par l'utilisation de l'anti-idiotype humanisé en tant qu'agent d'élimination des anticorps anti-CEA ou des fragments de ces anticorps. On peut également utiliser l'anti-idiotype humanisé en tant que vaccin immunogène.

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