C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12P 21/02 (2006.01) C40B 40/08 (2006.01)
Patent
CA 2536238
The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies immunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The present invention also provides antibodies produced by the methods of the invention.
La présente invention concerne des méthodes de remise au point ou de remise en forme d'anticorps afin de réduire l'antigénicité des anticorps, tout en maintenant l'immunospécificité des anticorps pour un antigène. La présente invention concerne, en particulier, des méthodes de production d'anticorps immunospécifiques pour un antigène par synthèse d'une bibliothèque combinatoire comprenant des régions (CDRs) de détermination de la complémentarité d'un anticorps donneur fondu par sa structure aux régions d'infrastructure d'une sous-banque de régions d'infrastructure. La présente invention concerne également des anticorps obtenus à l'aide des méthodes de l'invention.
Dall-Acqua William
Damschroder Melissa
Wu Herren
Medimmune Inc.
Smart & Biggar
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