Humanization of murine antibody

Details Humanization of murine antibody Humanization of murine antibody

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2312208

A humanized murine antibody is provided. The amino acid sequences of a light chain complementarity determining region from a mouse antibody are grafted onto a human light chain, and a heavy chain complementarity determining region from a mouse antibody are grafted onto a human antibody heavy chain to produce libraries from which a humanized murine antibody having the desired specificity is selected.

L'invention concerne un anticorps murin humanisé. Les séquences d'acides aminés d'une région de détermination de complémentarité, de chaîne légère, d'un anticorps de souris, sont greffées sur une chaîne légère humaine, et d'une région de détermination de complémentarité, de chaîne lourde, d'un anticorps de souris, sont greffées sur une chaîne lourde d'anticorps d'humain, de sorte que des banques soient produites, à partir desquelles un anticorps murin humanisé ayant la spécificité voulue est sélectionné.

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