Humanization of rabbit antibodies using a universal antibody...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 16/22 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2728004

The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.

La présent invention concerne une infrastructure d'acceptation d'anticorps universelle et des méthodes pour greffer des anticorps non humains, par exemple des anticorps de lapin, au moyen d'une infrastructure d'acceptation d'anticorps universelle. Les anticorps générés par les méthodes de l'invention sont utiles dans diverses applications diagnostiques et thérapeutiques.

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