Humanized and chimeric monoclonal antibodies that recognize...

Details Humanized and chimeric monoclonal antibodies that recognize... Humanized and chimeric monoclonal antibodies that recognize...

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2332183

The invention relates to new humanized and chimeric monoclonal antibodies that recognized EGF-R comprising an artificial sequence at least of the FRs of the heavy chain variable region of a human inmunoglobulin . The hypervariable regions of both monoclonal antibodies is the following amino acid sequence: light chain : CDR-1:-arg-ser-ser-gln-asn-ile-val-his-ser-asn-gly-asn-thr-tyr-leu- asp;CDR-2:- lys-val-ser-asn-arg-phe-ser; CDR-3:-phe-gln-tyr-ser-hys-val-pro-trp-thr. Heavy chain: CDR-1:- asn-tyr-tyr-ile-tyr; CDR-2:-gly-ile-asn-pro-thr-ser-gly-gly-ser- asn- phe-asn- glu-lys-phe-lys-thr; CDR-3:-gln-gly-leu-trp-phe-asp- ser-asp-gly-arg-gly-phe- asp-phe. The antibodies can be used for therapeutical and diagnostic purposes.

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