Humanized anti-a9 integrin antibodies and the uses thereof

Details Humanized anti-a9 integrin antibodies and the uses thereof Humanized anti-a9 integrin antibodies and the uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2711771

The present invention provides humanized antibodies that immunospecifically recognize human .alpha.9 integrin. Some of these antibodies inhibit the biological functions of the .alpha.9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with a9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

La présente invention porte sur des anticorps humanisés qui reconnaissent de façon immunospécifique l'intégrine a9 humaine. Une partie de ces anticorps inhibent les fonctions biologiques de l'intégrine a9, manifestant de cette façon des effets thérapeutiques sur divers troubles ou maladies qui sont associées à l'intégrine a9, comprenant le cancer, par exemple la croissance et la métastase d'une cellule cancéreuse, et des maladies inflammatoires, par exemple, la polyarthrite rhumatoïde, l'arthrose, l'hépatite, l'asthme, une fibrose, le diabète, l'artériosclérose, la sclérose en plaques, un granulome, une maladie inflammatoire de l'intestin (colite ulcéreuse et maladie de Crohn), une maladie auto-immune, etc.

Affiliated with

Also associated with

Rating

Humanized anti-a9 integrin antibodies and the uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Humanized anti-a9 integrin antibodies and the uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Humanized anti-a9 integrin antibodies and the uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1764356