C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2714296
The present invention is directed to humanized antibodies which bind the human C5a receptor and their use as therapeutic and diagnostic agents. The present invention is further directed toward nucleic acid sequences which encode said humanized antibodies, and their expression in recombinant host cells. In particular, the present invention is directed towards humanized antibodies derived from murine antibody 7F3 which specifically binds to the human C5a receptor.
La présente invention concerne des anticorps humanisés qui se lient au récepteur C5a humain, ainsi que leur utilisation en tant qu'agents thérapeutiques et de diagnostic. La présente invention concerne également des séquences d'acides nucléiques codant lesdits anticorps humanisés et leur expression dans des cellules hôtes recombinées. La présente invention concerne, en particulier, des anticorps humanisés issus de l'anticorps murin 7F3 qui se lie de façon spécifique au récepteur C5a humain.
Mackay Charles
Whitfeld Peter
Zahra David
G2 Inflammation Pty Ltd
Smart & Biggar
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