Humanized anti-ccr2 antibodies and methods of use therefor

Details Humanized anti-ccr2 antibodies and methods of use therefor Humanized anti-ccr2 antibodies and methods of use therefor

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2529694

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

L'invention concerne un anticorps humanisé, ou un fragment fonctionnel de celui-ci, se liant à un mammifère (par exemple, humain), du type comprenant un récepteur de chimiokine-CC (CCR2) ou une portion du récepteur, et des liaisons de séquences d'un ligand au récepteur. L'invention concerne en outre un procédé d'inhibition de l'interaction d'une cellule porteuse de CCR2 mammifère avec un ligand de celui-ci, ainsi que l'utilisation des anticorps et fragments de ceux-ci dans des procédés thérapeutiques, prophylactiques et de diagnostic.

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