C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2399080
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor (2) (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
La présente invention se rapporte à un anticorps humanisé ou à un fragment fonctionnel d'un tel anticorps qui se lie à un récepteur (2) mammalien (par exemple, humain) de chimiokine-CC (CCR2) ou à une partie d'un tel récepteur et bloque la liaison d'un ligand au récepteur. L'invention se rapporte également à un procédé d'inhibition de l'interaction d'une cellule portant un CCR2 mammalien avec un ligand associé, et à l'utilisation de ces anticorps et fragments dans des méthodes thérapeutiques, prophylactiques et diagnostiques.
Horvath Christopher
Jones S. Tarran
Larosa Gregory J.
Newman Walter
O'brien Siobhan
Gowling Lafleur Henderson Llp
Millennium Pharmaceuticals Inc.
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