Humanized anti-cd11a antibodies

Details Humanized anti-cd11a antibodies Humanized anti-cd11a antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2272842

Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50(nM) value of no more than about 1nM in the mixed lymphocyte response assay.

L'invention concerne des anticorps anti-CD11a humanisés et leurs diverses utilisations. L'anticorps anti-CD11a humanisé peut se fixer spécifiquement sur le domaine I du CD11a humain, avoir une IC50(nM) inférieure ou égale à 1 nM environ, de façon à empêcher l'adhésion des cellules de Jurkat sur les kératinocytes épidermiques humains normaux exprimant l'ICAM-1, et/ou une IC50(nM) inférieure ou égale à 1 nM environ dans le test de réaction lymphocytaire mixte.

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