C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2662340
The present invention provides chimeric and humanized versions of anti-CD 19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD 19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders, such as, but not limited to, B cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft- versus-host disease (GVHD), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.
LA présente invention fournit des versions chimériques et humanisées d'anticorps monoclonaux anti-CD19 de souris. L'invention concerne en outre des compositions pharmaceutiques, des compositions immunothérapeutiques et des procédés utilisant des anticorps thérapeutiques qui se lient à l'antigène CD19 humain et qui peuvent atténuer les ADD, les CDC, et/ou une apoptose pour le traitement des maladies et troubles de la cellules B, tels que, mais sans s'y limiter, des tumeurs malignes de cellules B, pour le traitement et la prévention de maladies auto-immunes, et pour le traitement et la prévention de réaction de greffe contre hôte (GVHD), un rejet humoral, et un désordre lymphoprolifératif post-transplantation chez des receveurs humains de transplantation.
Coyle Anthony
Dall'acqua William
Damschroder Melissa
Herbst Ronald
Kiener Peter
Medimmune Llc
Smart & Biggar
LandOfFree
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