C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 35/02 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2545166
A humanized antibody binding to CD47; a diabody antibody binding to human CD47 which is characterized by having a disulfide bond between fragments constituting the diabody; a gene encoding any of the above antibodies; a vector containing this gene; a host cell containing this vector; a process for producing an antibody comprising the step of culturing this host cell; and a remedy for a blood disease containing the above antibody.
La présente invention a trait à un anticorps anti-CD47 humanisé ; à un anticorps de forme dimérique dite <=diabody>= de liaison à un CD47 humain qui est caractérisé en ce qu'il comporte une liaison disulfure entre des fragments constituant la forme dimérique dite <=diabody>=; à un gène codant pour un quelconque desdits fragments ; à un vecteur contenant ledit gène ; à une cellule hôte contenant ledit vecteur ; à un procédé pour la production d'un anticorps comprenant une étape de culture de ladite cellule hôte ; et à un remède pour une maladie du sang contenant ledit anticorps.
Fukushima Naoshi
Iijima Shigeyuki
Kikuchi Yasufumi
Kinoshita Yasuko
Tsuchiya Masayuki
Chugai Seiyaku Kabushiki Kaisha
Fukushima Naoshi
Iijima Shigeyuki
Kikuchi Yasufumi
Kinoshita Yasuko
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