Humanized anti-cd70 binding agents and uses thereof

Details Humanized anti-cd70 binding agents and uses thereof Humanized anti-cd70 binding agents and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2605507

Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

L'invention concerne des agents de liaison à CD70, par exemple des anticorps anti-CD70 humanisés, des fragments et des dérivés de ceux-ci, exerçant une activité cytotoxique, cytostatique ou immunomodulatoire sur les cellules exprimant CD70, ainsi que des compositions pharmaceutiques et des kits contenant l'anticorps, le fragement ou le dérivé. L'invention concerne également des méthodes de traitement des cancers exprimant CD70 et des troubles immunologiques, consistant à administrer à un sujet des agents de liaison à CD70 ou des compositions pharmaceutiques.

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