C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/26 (2006.01) A61P 3/06 (2006.01)
Patent
CA 2638869
Provided are humanized monoclonal antibodies, and antigen-binding portions thereof, which bind acylated and unacylated human ghrelin. Such antibodies are useful for neutralizing ghrelin activity and treating disorders in which ghrelin activity is detrimental, including obesity and related disorders, and various cancers.
L'invention concerne des anticorps monoclonaux humanisés et des parties de ceux-ci se liant à un antigène, lesquels se lient à un Ghrelin humain acylé et non acylé. De tels anticorps sont utiles pour neutraliser une activité Ghrelin et traiter des troubles dans lesquels l'activité Ghrelin est nuisible, y compris l'obésité et troubles apparentés ainsi que différents cancers.
Marquis David Matthew
Smith Eric Michael
Subramaniam Danise Rogers
Witcher Derrick Ryan
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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