C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/44 (2006.01) A61P 7/06 (2006.01) A61P 35/00 (2006.01) C12P 21/08 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2708407
The present invention provides a humanized anti-human CD34 antibody and the preparation method thereof. The humanized anti-human CD34 antibody retains the affinity and specificity of its original murine-derived antibody. The antibody can be conjugated with magnetic nano materials to prepare immunomagnetic beads to screen marrow hemopoietic stem cells. It can effectively reduce the incidence rate of HAMA and improve the security of clinical transplantation of hemopoietic stem cells and can be used in treatment of certain malignant hematologic diseases and solid tumors.
L'invention concerne un anticorps monoclonal anti-CD34 humanisé et sa préparation. L'anticorps monoclonal anti-CD34 humanisé garde l'affinité et la spécificité de son anticorps monoclonal murin d'origine. L'anticorps peut être conjugué avec un nanomatériau magnétique pour fabriquer des billes immunomagnétiques pour cribler des cellules souches hémopoïétiques de moelle. Il peut réduire efficacement le taux d'incidence de l'HAMA et améliorer la sécurité d'une transplantation clinique de cellules souches hémopoïétiques, et il peut être utilisé dans le traitement de certaines maladies hématologiques malignes et de tumeurs solides.
Guo Yajun
Hou Sheng
Li Bohua
Ma Jing
Qian Weizhu
Cassan Maclean
Shanghai Guojian Bio-Tech Institute
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