C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2232828
The invention provides humanized anti-human Fas antibodies capable of inducing apoptosis in cells expressing Fas and which are useful in the treatment of autoimmune disease and chronic rheumatoid arthritis. In addition, the invention provides DNA encoding the variable regions of the H and L chain of such antibodies and methods for humanizing antibodies.
L'invention concerne des anticorps Fas anti-humains humanisés capables d'induire une apoptose dans les cellules exprimant Fas qui sont utiles dans le traitement des maladies auto-immunes et de la polyarthrite rhumatoïde. De plus, l'invention contient de l'ADN codant pour les régions variables de la chaîne H et L de ces anticorps et des méthodes pour humaniser les anticorps.
Haruyama Hideyuki
Nakahara Kaori
Serizawa Nobufusa
Takahashi Tohru
Yonehara Shin
Marks & Clerk
Sankyo Company Limited
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