C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2653661
It is intended to provide a humanized anti-human osteopontin antibody which is superior to conventional anti-human osteopontin antibodies in terms of activities (an antigen-binding activity, a leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, hypoxic conditions or denaturants, and the like).
La présente invention concerne un anticorps d'ostéopontine anti-humain humanisé supérieur aux anticorps d'ostéopontine anti-humains classiques en termes d'activités (une activité de liaison à l'antigène, une activité inhibitrice de migration leucocytaire et analogues) et/ou de stabilité (résistance à la chaleur, aux conditions hypoxiques ou dénaturantes, et analogues).
Higuchi Hirofumi
Nakashima Toshihiro
Sakai Fumihiko
Torikai Masaharu
Yamamoto Nobuchika
Astellas Pharma Inc.
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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