Humanized anti-tag-72 monoclonal antibodies

Details Humanized anti-tag-72 monoclonal antibodies Humanized anti-tag-72 monoclonal antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2569200

The present invention relates to humanized antibodies specific to a tumor- associated glycoprotein, TAG-72, and anticancer compositions comprising the humanized antibodies. In detail, the present invention relates to a humanized antibody which has enhanced antigen binding affinity by mutating a heavy chain of a humanized antibody PXA/HzK specific for TAG-72, an antibody which is prepared by replacing a light chain of the humanized antibody with a human light chain, and anticancer compositions including the antibodies.

L'invention concerne des anticorps humanisés spécifiques à une glycoprotéine associée à la tumeur, TAG-72, et des compositions anticancéreuses qui renferment ces anticorps. De façon détaillée, l'invention concerne un anticorps humanisé à affinité de liaison d'antigène améliorée par mutation d'une chaîne lourde d'anticorps humanisé AKA/HzK spécifique au TAG-72, un anticorps qui est élaboré sous remplacement d'une chaîne légère de l'anticorps humanisé par une chaîne humaine légère, et des compositions anticancéreuses comportant les anticorps.¿?

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