C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2212750
The invention provides a humanized antibody that specifically binds to a CD3 antigen on the surface of T cells. The antibody comprises complementary determining regions derived from corresponding regions of the mouse M291 immunoglobulin light and heavy chains and variable region frameworks from a human kappa light chain variable region framework sequence and a human heavy chain variable region framework sequence. At least one position in the human heavy chain variable region framework sequence selected from H30, H67, H68, H70, H72 and H74 is occupied by the same amino acid present in the equivalent position of the M291 immunoglobulin heavy chain variable region framework. The humanized immunoglobulin has greater binding affinity for the CD3 antigen than the M291 immunoglobulin.
L'invention décrit des anticorps bispécifiques ayant une cytotoxicité sélective contre les cellules B malignes. Lesdits anticorps bispécifiques se lient à un antigène de cellule effectrice ainsi qu'à une protéine hétérodimère de 28/32 kDa sur la surface de cellules B malignes. L'invention concerne aussi les constituants monospécifiques desdits anticorps bispécifiques, des versions humanisées de ceux-ci et des anticorps bispécifiques humanisés. L'invention décrit également des méthodes thérapeutiques et diagnostiques faisant intervenir ces anticorps.
Gingrich Roger
Link Brian K.
Tso J. Yun
Weiner George
Abbott Biotherapeutics Corp.
Fetherstonhaugh & Co.
Iowa Immunotherapy Investigators
Protein Design Labs Inc.
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