Humanized antibodies against icam-1, their production and uses

Details Humanized antibodies against icam-1, their production and uses Humanized antibodies against icam-1, their production and uses

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2454361

The invention provides humanized antibodies, for example, those that that bind ICAM-1, methods of use and methods of producing the antibodies. Antibodies include sequences having a VH and VL domain selected from HumA, HumB, HumC, HumD, HumE, HumF, HumG, HumH, HumI, Hum40 and Hum50.

L'invention concerne des anticorps humanisés, par exemple les anticorps liant ICAM-1, des procédés d'utilisation ainsi que des procédés de fabrication de ceux-ci. Les anticorps selon l'invention comportent des séquences présentant un domaine? ¿V<SB>H </SB>et V<SB>L</SB>, choisies dans HumA, HumB, HumC, HumD, HumE, HumF, HumG, HumH, HumI, Hum40 et Hum50.

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