Humanized antibodies against light and uses thereof

Details Humanized antibodies against light and uses thereof Humanized antibodies against light and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2756186

The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation).

La présente invention porte sur des polypeptides se fixant à un antigène, ou des variants ou dérivés de ceux-ci, qui se fixent spécifiquement au polypeptide LIGHT. L'invention porte également sur des procédés de fabrication et d'utilisation de tels anticorps, en particulier dans le traitement ou le diagnostic de maladies ou affections immunes, inflammatoires et malignes (par exemple une affection abdominale inflammatoire ; la maladie de Crohn, la recto-colite hémorragique, la sclérose en plaques, la polyarthrite rhumatoïde et une greffe).

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