Humanized antibodies against the .beta.-amyloid peptide

Details Humanized antibodies against the .beta.-amyloid peptide Humanized antibodies against the .beta.-amyloid peptide

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2704064

The invention discloses an isolated antibody that selectively binds to the C- terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerisation of Abeta. Furthermore, a method of diagnosis comprising the steps of. (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.

L'invention porte sur un anticorps isolé qui se lie sélectivement à la partie C-terminale d'Abeta et est humanisé ou entièrement humain. L'anticorps de l'invention est apte à empêcher l'oligomérisation d'Abeta. De plus, l'invention porte sur un procédé de diagnostic comprenant les étapes consistant à : (i) marquer un anticorps; (ii) administrer une dose efficace dudit anticorps par voie intranasale ou systémique à un sujet; et (iii) détecter la concentration et/ou la présence de l'anticorps marqué dans des parties du corps du sujet.

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