Humanized antibodies and uses thereof

Details Humanized antibodies and uses thereof Humanized antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2178622

The present invention relates to humanized antibodies and bind- ing proteins thereof, capable of binding to T cells exhibiting particular variable beta chains, and particularly those subpopulations expressing human V.beta. 5.2 and/or 5.3 and V.beta. 8.1. The present invention also relates to the preparation of such antibodies, to pharmaceutical compo- sitions containing them, and therapeutic utilization of the antibodies, specifically in autoimmune diseases.

Anticorps humanisés et leurs protéines liantes, pouvant se lier aux lymphocytes T présentant des chaînes bêta variables particulières, et notamment certaines sous-populations qui expriment la V.beta. 5,2 et/ou 5,3 humaine, ainsi que la V.beta. 8,1; préparation de ces anticorps; compositions pharmaceutiques les contenant; et application thérapeutique desdits anticorps, notamment au traitement des maladies auto-immunes.

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