Humanized antibodies derived from dd-3b6/22, specific for...

Details Humanized antibodies derived from dd-3b6/22, specific for... Humanized antibodies derived from dd-3b6/22, specific for...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61B 6/00 (2006.01) A61B 6/03 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) A61P 7/00 (2006.01) A61P 7/02 (2006.01) C07K 16/18 (2006.01) C07K 16/36 (2006.01) C07K 16/46 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2450828

The present invention is directed to humanised forms of the mouse monoclonal antibody DD-3B6/22. This antibody is specific for D-dimer, a degradation fragment of crosslinked fibrin polymers. The invention also includes the use of these antibodies to detect blood clots in vivo.

L'invention concerne des formes humanisées de l'anticorps monoclonal DD-3B6/22 de souris. Cet anticorps est spécifique de D-dimère, un fragment de dégradation de polymères de fibrine réticulés. L'invention concerne également l'utilisation de ces anticorps pour détecter des caillots sanguins <i>in vivo</i>.

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