C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2721716
The present invention provides humanized antibodies that immunospecifically recognize the RGD sequence. Some of these antibodies inhibit the biological functions of the RGD proteins, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with RGD proteins, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, endometriosis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.
La présente invention porte sur des anticorps humanisés qui reconnaissent de façon immunospécifique la séquence RGD. Certains de ces anticorps inhibent les fonctions biologiques des protéines RGD, si bien qu'ils présentent des effets thérapeutiques sur divers troubles ou maladies qui sont associés aux protéines RGD, dont le cancer, par exemple le développement et la métastase d'une cellule cancéreuse, et des maladies inflammatoires, par exemple la polyarthrite rhumatoïde, l'arthrose, l'hépatite, l'endométriose, l'asthme, une fibrose, le diabète, l'artériosclérose, la sclérose en plaques, un granulome, une maladie intestinale inflammatoire (rectocolite hémorragique et maladie de Crohn), une maladie auto-immune et ainsi de suite.
Kon Shigeyuki
Kumar Shankar
Tso J. Yun
Tsurushita Naoya
Uede Toshimitsu
Fetherstonhaugh & Co.
Gene Techno Science Co. Ltd.
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