Humanized antibodies that bind to cd19 and their uses

Details Humanized antibodies that bind to cd19 and their uses Humanized antibodies that bind to cd19 and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2753158

The present invention relates to humanized antibodies or fragments thereof that bind to human CD 19. More specifically, the present invention relates to a humanized antibody or fragment thereof that binds to human CD 19 comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 27, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 28, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 29; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 30, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 31 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 32.

La présente invention porte sur des anticorps humanisés ou des fragments de ceux-ci qui se fixent au CD19 humain. De façon plus spécifique, la présente invention porte sur un anticorps humanisé ou un fragment de celui-ci qui se fixe au CD19 humain, comprenant une chaîne lourde CDR1 comprenant la séquence d'acides aminés de SEQ ID N° : 27, et/ou une chaîne lourde CDR2 comprenant la séquence d'acides aminés de SEQ ID N° :28, et/ou une chaîne lourde CDR3 comprenant la séquence d'acides aminés de SEQ ID N° : 29 ; et/ou comprenant une chaîne légère CDR1 comprenant la séquence d'acides aminés de SEQ ID N° : 30, et/ou une chaîne légère CDR2 comprenant la séquence d'acides aminés de SEQ ID N° : 31 et/ou une chaîne légère CDR3 comprenant la séquence d'acides aminés de SEQ ID N° : 32.

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