Humanized antibodies that sequester alpha beta peptide

Details Humanized antibodies that sequester alpha beta peptide Humanized antibodies that sequester alpha beta peptide

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/00 (2006.01) A61P 25/28 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2400559

A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble A.beta. peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide A.beta..

Procédé de traitement prophylactique et thérapeutique d'états caractérisés par la formulation de plaques amyloïdes. Ce procédé consiste à mettre en application des anticorps humanisés séquestrant le peptide soluble A.beta. à partir de fluides biologiques humains ou se liant, de préférence, de façon spécifique à un déterminant antigénique contenu entre les positions 13-28 du peptide A.beta. amyloïde.

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