Humanized antibodies to fc receptors for immunoglobulin g on...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/46 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2148578

Humanized antibodies are described which are specific to an Fc receptor (FcR). The humanized antibodies have at least a portion of a complementarity determining region (CDR) derived from a non-human antibody, e.g. murine, with the remaining portions being human in origin. The use of humanized antibodies rather than murine antibodies inhuman therapy should alleviate some of the problems associated with the use of some murine monoclonal antibodies because only the substituted CDRs will be foreign to a human's immune system. The humanized antibodies can be used in the same manner as their murine counterparts.

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