Humanized antibodies with modified glycosylation

Details Humanized antibodies with modified glycosylation Humanized antibodies with modified glycosylation

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 1/113 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257357

The invention provides a method of reducing immunogenicity or toxicity of a therapeutic or diagnostic antibody in which a host system is selected for the characteristic that the system differentially glycosylatesan antibody or an antigen-binding antibody fragment, and a nucleotide sequence comprising nucleic acids encoding a therapeutic or diagnostic antibody is expressed in the host system.

Anticorps humanisés se liant à l'antigène NR-LU-13, conjugués contenant de tels anticorps et leur utilisation dans des procédés de préciblage et des techniques d'immunodiagnostic et de thérapies par anticorps classiques.

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