C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2555306
Novel humanized and chimeric antibodies, humanized antibody fragments, polypeptides sequences of such antibodies and derivatives thereof that specifically bind AF-20 are provided as well as methods for their manufacture. These humanized and chimeric antibodies, antibody fragments and polypeptide sequences are useful in the treatment of cancers that express AF-20, as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells that express AF-20.
L'invention concerne des anticorps humanisés et chimériques, des fragments d'anticorps humanisés, des séquences polypeptidiques de ces anticorps et des dérivés de ces éléments qui se lient spécifiquement à AF-20 ainsi que des procédés de fabrication desdits éléments. Ces anticorps humanisés et chimériques, ces fragments d'anticorps et ces séquences polypeptidiques conviennent au traitement des cancers qui expriment AF-20, et à des fins diagnostiques, par exemple, pour la mise en image in vivo de tumeurs ou de cellules cancéreuses qui expriment AF-20.
Averback Paul A.
Gemmell Jack
Mccarthy Tetrault Llp
Nymox Corporation
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