C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 31/20 (2006.01) C07K 16/08 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2351315
The present invention relates to humanized antibodies specific for HBV surface antigen pre-S1, which show binding affinity similar to mouse monoclonal antibody and which show remarkably reduced immunogenicity since they have less mouse-derived amino acid residues. Thus, the humanized antibodies of the present invention may be useful for the prevention of HBV infection and for the treatment of hepatitis B.
L'invention concerne des anticorps humanisés spécifiques pour l'antigène pre-S1 de surface de HBV, qui montrent une affinité similaire à l'anticorps monoclonal de la souris, ainsi qu'une immunogénicité remarquablement diminuée, étant donné qu'ils possèdent moins de résidus aminoacides dérivés de la souris. Ces anticorps humanisés peuvent, de ce fait, être utiles pour la prévention de l'infection par HBV et pour le traitement de l'hépatite B.
Hong Hyo Jeong
Hur Hyangsuk
Ryu Chun Jeih
Korea Green Cross Corporation
Korea Institute Of Science And Technology
Sim & Mcburney
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