C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2081479
2081479 9116928 PCTABS00008 The present invention discloses humanized chimeric antibodies which are capable of binding to the intercellular adhesion molecule ICAM-1. Specifically, disclosed are humanized anti-ICAM-1 antibodies of the IgG1, IgG2, and IgG4 subtype. These antibodies are useful in treating specific and non-specific inflammation, rhinoviral infection, HIV infection, the dissemination of HIV infected cells, and asthma. In addition, the humanized antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation and infection and tumors expressing ICAM-1.
Adair John Robert
Bright Susan Margaret
Robinson Martyn Kim
Rothlein Robert A.
Boehringer Ingelheim Pharmaceuticals Inc.
Celltech Therapeutics Limited
Gowling Lafleur Henderson Llp
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