Humanized collagen antibodies and related methods

Details Humanized collagen antibodies and related methods Humanized collagen antibodies and related methods

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2468016

The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarily determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

La présente invention concerne un anticorps greffé ou un fragment fonctionnel de ce dernier, comprenant une ou plusieurs régions déterminantes de complémentarité (CDR) renfermant au moins une substitution d'acide aminé dans au moins une CDR d'une CDR de chaîne lourde, l'anticorps greffé ou le fragment fonctionnel de ce dernier possédant une activité de liaison spécifique pour un épitope cryptique de collagène. L'invention se rapporte également à des procédés d'utilisation d'un anticorps possédant une activité de liaison spécifique pour un épitope cryptique de collagène, y compris à des procédés permettant d'inhiber l'angiogénèse, la croissance tumorale et la métastase.

Affiliated with

Also associated with

Rating

Humanized collagen antibodies and related methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Humanized collagen antibodies and related methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Humanized collagen antibodies and related methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1594926