C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2565874
The present invention relates to humanized Fc.gamma.RIIB antibodies, fragments, and variants thereof that bind human Fc.gamma.RIIB with a greater affinity than said antibody binds Fc.gamma.RIIA. The invention encompasses the use of the humanized antibodies of the invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune and inflammatory disease. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the humanized antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing the efficacy of a vaccine composition by administering the humanized antibodies of the invention. The invention encompasses methods for treating an autoimmune disease and methods for elimination of cancer cells that express Fc.gamma.RIIB.
Cette invention concerne l~humanisation d~anticorps Fc.gamma.RIIB, les fragments et variantes qui en découlent et qui rassemblent les Fc.gamma.RIIB humains de manière plus homogène que ne le sont les Fc.gamma.RIIA par les anticorps. Cette invention englobe l~utilisation de ces anticorps humanisés pour traiter toute maladie en rapport avec la perte d~équilibrage de signalisation chez le récepteur Fc, telle que le cancer, les maladies auto-immunes et les affections inflammatoires. Cette invention met à disposition des méthodes d~amélioration des effets thérapeutiques des anticorps thérapeutiques en appliquant les anticorps humanisés de cette invention pour augmenter la fonction thérapeutique de ces anticorps. Cette invention fournit également des méthodes de développement de l~efficacité d~une composition vaccinale administrant les anticorps humanisés de cette invention. Cette invention englobe les méthodes de traitement des maladies auto-immunes et d~élimination des cellules cancéreuses qu~expriment les Fc.gamma.RIIB.
Huang Ling
Johnson Leslie S.
Macrogenics Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
Humanized fc.gamma.riib specific antibodies and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Humanized fc.gamma.riib specific antibodies and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Humanized fc.gamma.riib specific antibodies and methods of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2067059