Humanized immunoglobulin reactive with b7 molecules and...

Details Humanized immunoglobulin reactive with b7 molecules and... Humanized immunoglobulin reactive with b7 molecules and...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 31/445 (2006.01) A61K 31/56 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/13 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 1/18 (2006.01) A61P 3/00 (2006.01) A61P 7/06 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2362592

The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.

L'invention concerne des anticorps humanisés anti-B7-2 et anti-B7-1, chacun comprenant une région variable d'origine non humaine ainsi qu'au moins une partie d'une immunoglobuline d'origine humaine. L'invention concerne également des méthodes de traitement de diverses maladies auto-immunes, de rejet du greffon, de troubles inflammatoires et de maladies infectieuses par l'administration d'anticorps humanisés anti-B7-2 et/ou anti-B7-1.

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