Humanized l243 antibodies

Details Humanized l243 antibodies Humanized l243 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 14/74 (2006.01)

Patent

CA 2599734

Humanized antibodies are provided that specifically bind HLA-DR. The antibodies recognize the epitope recognized by the murine monoclonal antibody L243. Processes for preparing such antibodies, pharmaceutical compositions containing such antibodies, and clinical therapuetic and diagnostic, as well as research-related uses for such antibodies, are provided.

L~invention a trait à des anticorps humanisés se liant spécifiquement aux HLA-DR. Les anticorps reconnaissent le site antigénique reconnu par l~anticorps monoclonal murin L243. L~invention concerne également des procédés de préparation de tels anticorps, ainsi que des compositions pharmaceutiques comprenant de tels anticorps, et des utilisations associées à la recherche, au diagnostic et au traitement clinique pour de tels anticorps.

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