Humanized monoclonal antibodies

Details Humanized monoclonal antibodies Humanized monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2096860

ABSTRACT OF THE DISCLOSURE A method of preparing humanized monoclonal antibodies is described which utilizes comparative model building methodology. A humanized anti-CD18 antibody, 60.3, has been formulated and demonstrated to have analogous binding characteristics to the original murine monoclonal antibody, while displaying essentially complete human Ig heavy and light chains.

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