C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2185112
Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Single-chain binding proteins, fusion proteins, and antigenic or IL.4 binding fragments of such antibodies are also provided by this invention. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.
L'invention concerne des anticorps monoclonaux humanisés, spécifiques contre IL-4 chez l'homme et possédant des propriétés très supérieures à celles d'autres anticorps humanisés disponibles précédemment. Elle concerne également des protéines de fixation monocaténaires, des protéines de fusion, ainsi que des fragments antigéniques ou de fixation à IL-4. Elle concerne encore des acides nucléiques codant les régions variables de chaîne lourde et légère de ces anticorps monoclonaux ou de leurs fragments antigéniques, des anticorps anti-idiotypiques, ainsi que des procédés de détection, de mesure et d'immunopurification de IL-4 chez l'homme, ainsi que de blocage ou d'imitation de l'activité biologique de IL-4 chez l'homme.
Dalie Barbara
Miller Kenneth
Murgolo Nicholas
Tindall Stephen
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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