C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/02 (2006.01)
Patent
CA 2571743
The present invention is directed to a CHO cell expression system for high level expression of a chimeric 31.1 monoclonal antibody specific for a human carcinoma-associated protein antigen. The present invention also provides a pharmaceutical composition comprising chimeric 31.1 monoclonal antibody derived from the CHO cells of the invention for use in immunotherapy or immunodiagnosis.
La présente invention concerne un système d'expression cellulaire CHO permettant l'expression à un niveau élevé d'un anticorps monoclonal 31.1 chimérique propre à un antigène protéique associé au carcinome. Cette invention concerne également une composition pharmaceutique comprenant un anticorps monoclonal 31.1 chimérique provenant de cellules CHO décrites dans l'invention, laquelle composition pharmaceutique peut être utilisée à des fins d'immunothérapie ou d'immunodiagnostic.
Fasick Jeffrey
Panayotatos Nikos
Tsang Kwong Y.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
International Bioimmune Systems Inc.
Neogenix Oncology Inc.
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