C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) G01N 33/68 (2006.01) G06F 9/00 (2006.01)
Patent
CA 2492524
The invention provides methods for producing a modified nucleic acid that encodes a modified a rabbit antibody so that the modified rabbit antibody is less immunogenic in a non-rabbit host than an unmodified parent rabbit antibody. The invention further provides modified nucleic acids made by these methods, as well as vectors and host cells comprising the nucleic acids, and methods for producing the encoded modified antibodies. Also provided are modified rabbit antibodies encoded by subject nucleic acids, and compositions containing the same. The invention further provides kits for carrying out the subject methods.
L'invention porte sur des procédés d'élaboration d'un acide nucléique modifié codant pour un anticorps modifié de lapin, moins immunogène dans un hôte différent d'un lapin qu'un anticorps parent non modifié de lapin. L'invention porte également: sur des acides nucléiques modifiés obtenus par ce procédé; sur des vecteurs et cellules hôtes comprenant lesdits acides nucléiques; sur des procédés de production desdits anticorps codés; sur des anticorps humanisés de lapin codés par lesdits acides nucléiques, sur des compositions les contenant; et sur des trousses de mise en oeuvre desdits procédés.
Couto Fernando Jose Rebelo Do
Pytela Robert
Yu Guoliang
Zhang Dongxiao
Epitomics Inc.
Fetherstonhaugh & Co.
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