C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/04 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2532430
Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
La présente invention concerne des conjugués cytotoxiques comprenant un agent de liaison cellulaire et un agent cytotoxique, des compositions thérapeutiques comprenant le conjugué, des procédés pour utiliser ces conjugués pour inhiber la croissance cellulaire et traiter des maladies, ainsi qu'un kit comprenant le conjugué cytotoxique. En particulier, l'agent de liaison cellulaire est un anticorps monoclonal, et des fragments de liaison d'épitope de celui-ci, qui reconnaît/reconnaissent et se lie(nt) au glycotope CA6. L'invention a également pour objet des versions resurfacées, adaptées à l'être humain de DS6, un anticorps monoclonal de souris anti-CA6, et des fragments de liaison d'épitope de celui-ci.
Chun Philip
Payne Gillian
Tavares Daniel J.
Gowling Lafleur Henderson Llp
Immunogen Inc.
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