Humoral hypercalcemic factor antagonists

Details Humoral hypercalcemic factor antagonists Humoral hypercalcemic factor antagonists

C - Chemistry, Metallurgy

07

K

167/103, 150/9,

C07K 14/635 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1321281

7616P/5485A 17716Y TITLE OF THE INVENTION HUMORAL HYPERCALCEMIC FACTOR ANTAGONISTS ABSTRACT OF THE INVENTION The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide analogues is exemplified by an internal region of the N-terminus of humoral hypercalcemic factor hHCF, and truncations thereof: hHCF(14-34)NH2, hHCF(13-34)NH2, hHCF(12-34)NH2, hHCE(11-34)NH2, hHCF(10-34)NH2, hHCF(9-34)NH2, hHCF(8-34)NH2, hHCF(7-34)NH2, hHCF(6-34)NH2, hHCF(5-34)NH2, hHCF(4-34)NH2, hHCF(3-34)NH2, and these peptides containing various amino acid substitutions.

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