Huntingtin-associated protein

Details Huntingtin-associated protein Huntingtin-associated protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/541 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2237183

Proteins which specifically bind to huntingtin, the product of the Huntington's Disease locus (HD), are used in assays for screening drug candidates. These proteins, termed huntingtin associated proteins, bind to huntingtins of both normal and Huntington's Disease patients. However, the binding is stronger to the huntingtins from the patients. The strength of binding correlates with the number of glutamine repeats in the huntingtin, which itself correlates with the time of disease onset.

Protéines se liant spécifiquement à la huntingtine, le produit du site de la chorée de Huntington, qui sont utilisées dans des analyses destinées à détecter des médicaments potentiels. Ces protéines, appelées protéines associées à la huntingtine, se lient à la huntingtine tant des patients normaux que des patients atteint de la chorée de Huntington. Toutefois, la liaison est plus forte chez les patients atteints de la chorée de Huntington. La force de la liaison est en corrélation avec le nombre de répétitions de la glutamine dans la huntingtine, qui est lui-même en corrélation avec le moment d'apparition de la maladie.

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