C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/10 (2006.01) C07K 1/107 (2006.01) C12P 19/04 (2006.01) C12P 19/26 (2006.01)
Patent
CA 2469566
A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. Methods of producing hyaluronic acid utilizing a recombinant host cell having an expression construct encoding the functionally active hyaluronan synthase with altered enzymatic activity are also disclosed.
L'invention concerne une hyaluronan synthase fonctionnellement active dont au moins un reste d'acide aminé est transformé par comparaison à une hyaluronan synthase native fonctionnellement active correspondante de sorte que la hyaluronan synthase fonctionnellement active présente une activité enzymatique modifié par comparaison à la hyaluronan synthase native fonctionnellement active correspondante. L'invention concerne également des procédés de production d'acide hyaluronique utilisant une cellule hôte de recombinaison dont la construction d'expression code pour la hyaluronan synthase fonctionnellement active à activité enzymatique modifiée.
Kumari Kshama
Weigel Paul H.
Marks & Clerk
The Board Of Regents Of The University Of Oklahoma
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