Hyaluronic acid anti-adhesion barrier

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/36 (2006.01) A61L 31/04 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61P 17/02 (2006.01) C08J 9/28 (2006.01) C08L 5/08 (2006.01)

Patent

CA 2377544

Methods of forming crosslinked hyaluronic acid anti-adhesion barriers, crosslinked hyaluronic acid anti-adhesions barriers, methods for preventing or inhibiting adhesions, and methods of promoting healing of a wound are provided. The method of forming the crosslinked hyaluronic acid anti-adhesion barrier includes freeze-drying a solution including hyaluronic acid to form a hyaluronic acid foam, which is then reacted with a crosslinking agent to form a crosslinked hyaluronic acid foam. The crosslinked hyaluronic acid foam is mixed with a solution containing hyaluronic acid to form an anti-adhesion barrier.

Cette invention concerne des procédés d'obtention de barrières anti-adhésion à base d'acide hyaluronique réticulé, les barrières anti-adhésion à base d'acide hyaluronique réticulé elles-mêmes, des procédés propres à empêcher ou à inhiber les adhésions et des procédés favorisant la cicatrisation de lésions. Pour l'obtention de barrières anti-adhésion à base d'acide hyaluronique réticulé, on congèle une solution renfermant de l'acide hyaluronique pour former une mousse d'acide hyaluronique, mousse qui, soumise à une réaction avec un agent réticulant, forme une mousse d'acide hyaluronique réticulé. Mélangée à une solution renfermant de l'acide hyaluronique, cette mousse d'acide hyaluronique réticulé forme une barrière anti-adhésion.

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