Hyaluronic acid as dna carrier for gene therapy and vegf...

A - Human Necessities – 61 – K

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Details

A61K 47/36 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2235685

The invention provides methods and compositions for gene therapy, including antisense therapy. In one embodiment, the compositions comprise hyaluronic acid to promote uptake of nucleic acid by the target cells. The invention is illustrated with reference to treatment of retinal diseases caused by neovascularisation.

Cette invention porte sur des méthodes de thérapie génique ainsi que sur les compositions correspondantes, y compris une thérapie anti-sens. Dans un mode de réalisation, les compositions contiennent de l'acide hyaluronique afin de stimuler l'absorption d'acide nucléique par les cellules cibles. A titre d'exemple, cette invention trouve une application dans le traitement de maladies rétiniennes causées par une néoformation de vaisseaux sanguins.

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