Hyaluronic acid-based gels including anesthetic agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 8/73 (2006.01) A61K 47/36 (2006.01) A61L 27/20 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61Q 19/08 (2006.01) A61K 31/167 (2006.01)

Patent

CA 2732928

Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

La présente invention concerne des remplissages de tissu mou, par exemple des remplissages dermiques et sous-dermiques, à base dacides hyaluroniques et des sels pharmaceutiquement acceptables de ceux-ci. Dans un aspect, les compositions à base dacide hyaluronique présentement décrites comprennent une quantité thérapeutiquement efficace dau moins un agent anesthésique, par exemple la lidocaïne. Les présentes compositions à base dacide hyaluronique comprenant de la lidocaïne ont une stabilité améliorée, par rapport à des compositions comprenant de la lidocaïne conventionnelles, par exemple lorsquelles sont soumises à des techniques de stérilisation ou lorsquelles sont conservées pendant de longues durées. La présente invention concerne en outre des procédés et des procédures de préparation de telles compositions à base dacide hyaluronique.

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