Hyaluronic acid-based gels including lidocaine

A - Human Necessities – 61 – K

Patent

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Details

A61K 8/73 (2006.01) A61L 27/20 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61Q 19/08 (2006.01) A61K 31/167 (2006.01)

Patent

CA 2732788

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

Linvention concerne des matières de remplissage cohésives pour tissus mous, par exemple des matières de remplissage dermiques et sous-dermiques, à base dacides hyaluroniques et de leurs sels pharmaceutiquement acceptables. Selon un aspect, les compositions à base dacide hyaluronique décrites dans le présent document comprennent une quantité thérapeutiquement efficace dau moins un agent anesthésique, par exemple la lidocaïne. Les présentes compositions à base dacide hyaluronique contenant de la lidocaïne présentent une stabilité et une cohésion améliorées, par rapport aux compositions classiques contenant de la lidocaïne, par exemple lorsquelles sont soumises à des techniques de stérilisation ou lorsquelles sont stockées pendant de longues périodes. Linvention concerne également des procédés de préparation de telles compositions à base dacide hyaluronique.

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