Hyaluronic acid binary mixtures and therapeutic use thereof

A - Human Necessities – 61 – K

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A61K 31/728 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2651039

The present invention is related to hyaluronic acid compositions consisting in a binary mixtures of hyaluronic acid samples having mainly different weight-average molecular weight and then different rheological properties in aqueous solution. The resulting compositions have demonstrated peculiar rheological behaviour with a balance between viscosity and viscoelasticity. Accordingly, these compositions of hyaluronic acid are useful for treatment of joint diseases by intra-articular administration or extra-articular application in soft tissue disorders.

La présente invention concerne des compositions d'acide hyaluronique consistant de mélanges binaires d'échantillons d'acide hyaluronique ayant principalement des masses moléculaires moyennes pondérales différentes et donc des propriétés rhéologiques en solution aqueuse différentes. Les compositions résultantes ont démontré un comportement rhéologique particulier avec un équilibre entre viscosité et visco-élasticité. En conséquence, ces compositions d'acide hyaluronique sont utiles pour le traitement de maladies des articulations par administration intra-articulaire ou application extra-articulaire dans des troubles des tissus mous.

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